Effects of alpha-melanocyte stimulating hormone on fever caused by endotoxin in rabbits.
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چکیده
منابع مشابه
Alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation.
Alpha-Melanocyte-stimulating hormone (MSH) is a potent anti-inflammatory agent in many models of inflammation, suggesting that it inhibits a critical step common to different forms of inflammation. We showed previously that alpha-MSH inhibits nitric oxide (NO) production in cultured macro-phages. To determine how alpha-MSH acts in vivo, we induced acute hepatic inflammation by administering end...
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alpha-Melanocyte-stimulating hormone (alpha-MSH), a 13-amino acid peptide produced in the brain and pituitary gland, is a regulator of appetite and body weight, and its production is regulated by leptin, a factor that affects bone mass when administered centrally. alpha-MSH acts via melanocortin receptors. Humans deficient in melanocortin receptor 4 (MC4-R) have increased bone mass, and MC4-R h...
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The preputial glands in the rat are large modified sebaceous glands, which are believed to be the source of a sex pheromone (Gawienowski et al., 1975). Their main secretory product is neutral lipid, which contains an unusually high proportion of squalene as well as wax esters and glyceryl ether lipids (Nicolaides, 1965; Helmy & Hack, 1967). Like cutaneous sebaceous glands their secretion is hol...
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Peptides of the pro-opiocortin class produce pronounced cardiovascular and natriuretic actions. We have investigated the acute cardiovascular effects of one of the most potent members of this class, y2-melanocyte stimulating hormone (y2-MSH), in rats. Pressor actions of y2MSH administered systemicaMy were eliminated by ganglionic blockade with chlorisondamine. Peripheral cholinergic blockade fa...
متن کاملInhibition of endotoxin-induced uveitis and potentiation of cyclooxygenase-2 protein expression by alpha-melanocyte-stimulating hormone.
PURPOSE The efficacy of alpha-melanocyte-stimulating hormone (alpha-MSH) on endotoxin-induced uveitis (EIU) was investigated in rats. Several studies have demonstrated that there are various inflammatory reactions mediated by an alpha-MSH receptor in macrophages. In addition, as it is known that cyclooxygenase (COX)-2 is induced by a variety of stimuli and plays an important role in inflammatio...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1991
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1991.sp018762